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Acoustic comfort in hospitals is vital for staff performance and patient safety, yet it remains a critical challenge in healthcare design. This paper presents the preliminary results of the BRIC INAIL 2024 project (ID07), aimed at defining a standardized protocol to assess the extra-auditory effects of noise on healthcare workers. The study characterizes the acoustic environment of selected Italian public and private hospitals through an observational approach involving three levels of depth: preliminary noise monitoring, room acoustic characterization, and integrated environmental-biomedical assessment. Preliminary measurements reveal that sound pressure levels significantly exceed WHO recommendations, with high sound dynamics (ΔL ≈ 13 dBA) and excessive reverberation times. Based on these findings, specific intervention strategies—including the installation of high-efficiency sound-absorbing materials—were designed and simulated. The results demonstrate a substantial predicted reduction in reverberation.