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Description
Overall photoacoustic (PA) wave field in blood is strongly influenced by acoustic scattering arising from spatial distribution and acoustic properties of red blood cells (RBCs). In this study, the effect of multiple scattering of acoustic waves in blood with 30% hematocrit is numerically investigated using the convergent Born series (CBS) method. The simulation result is compared with that of a discrete particle approach (DPA). While the DPA estimates the total pressure field as a linear superposition of fields emitted by individual particles, it neglects the contribution owing to multiple scattering of acoustic waves. The CBS method incorporates wave-cell interactions through an iterative Born series procedure. Simulations were performed for an ensemble of RBCs randomly distributed in a computational domain of size 2048x2048 grid points, and the pressure fields were calculated at 88 MHz for three different acoustic impedance mismatch conditions. The CBS technique can exhibit modification of the pressure field occurring due to multiple scattering of PA waves in blood.